Giant cell urothelial carcinoma is a rare variant of bladder cancer recognized by the current World Handriers Health Organization classification of urologic tumours.It is an aggressive tumour with a poor prognosis that usually presents at an advanced stage.It is characterized histologically by pleomorphic giant cells.We discuss a case of giant cell
Exploring the Phospholipid Transport Mechanism of ATP8A1-CDC50
P4-ATPase translocates lipids from the exoplasmic to the cytosolic plasma membrane leaflet Mag Pouches to maintain lipid asymmetry distribution in eukaryotic cells.P4-ATPase is associated with severe neurodegenerative and metabolic diseases such as neurological and motor disorders.Thus, it is important to understand its transport mechanism.However,
Rhythmic Relating: Bidirectional Support for Social Timing in Autism Therapies
We propose Rhythmic Relating for autism: a system of supports for friends, therapists, parents, and educators; a system which aims to augment bidirectional communication and complement existing therapeutic approaches.We begin by summarizing the developmental significance of social timing and the social-motor-synchrony challenges observed in early a
Watching a signaling protein function: What has been learned over four decades of time-resolved studies of photoactive yellow protein
Photoactive yellow protein (PYP) is a signaling protein whose internal p-coumaric acid chromophore undergoes reversible, light-induced trans-to-cis isomerization, which triggers a sequence of structural changes that ultimately lead to a signaling state.Since its discovery nearly 40 years ago, PYP has attracted much interest and has become one of th